Featured Publications

Bold denotes authors in the Kadoch Lab

Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain (Cell, 2017)

 
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Boulay, G.*, Sandoval, G.S.*, Riggi, N., Iyer, S., Buisson, R. Naigles, B., Awad, M.E., Rengarajan, S., Volorio, A., McBride, M.J., Broye, L.C., Zou, L., Stamenkovic, I., Kadoch, C.**, and Rivera, M.N.**. (2017) Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain. Cell. 171, 1–16 doi:10.1016/j.cell.2017.07.036 (* These authors contributed equally, ** Corresponding authors)

Dynamics of BAF-Polycomb complex opposition on heterochromatin in normal and oncogenic states (Nature Genetics, 2017)

 
 
 
 

Kadoch, C.*, Williams, R.T., Calarco, J.P., Miller, E.L., Weber, C.M., Braun, S.M.G., Pulice, J.L., Chory, E.J. and Crabtree. G.R.* (2016) Dynamics of BAF-Polycomb complex opposition on heterochromatin in normal and oncogenic states. Nat. Genet. 49, 213-222. doi:10.1038/ng.3734 (*Corresponding authors)

 
 

Proteomic and bioinformatic analysis of the mammalian SWI/SNF complexes identifies extensive roles in human malignancy (Nature Genetics, 2013)

 
 

Kadoch, C., Hargreaves, D.C., Hodges, C., Elias, L., Ho, L., Ranish, J. and Crabtree, G.R. (2013) Proteomic and bioinformatic analysis of the mammalian SWI/SNF complexes identifies extensive roles in human malignancy. Nat. Genet. 45, 592-602. doi:10.1038/ng.2628

 
 

Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma (Cell, 2013)

 
 

Kadoch, C. and Crabtree, G.R. (2013). Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma. Cell 153, 71-85. doi:10.1016/j.cell.2013.02.036

 

Full Publication List

2017

Boulay, G.*, Sandoval, G.S.*, Riggi, N., Iyer, S., Buisson, R. Naigles, B., Awad, M.E., Rengarajan, S., Volorio, A., McBride, M.J., Broye, L.C., Zou, L., Stamenkovic, I., Kadoch, C.**, and Rivera, M.N.**. (2017) Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain. Cell. 171, 1–16 doi:10.1016/j.cell.2017.07.036 (* These authors contributed equally, ** Corresponding authors)

Michel, B.C., and Kadoch, C. (2017). A SMARCD2-containing mSWI/SNF complex is required for granulopoiesis. Nat. Genet. 49, 655-657. doi:10.1038/ng.3853 (News and Views Article)

Pulice, J.L. and Kadoch, C. (2017). Composition and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Disease. Cold Spring Harb. Sym. doi:10.1101/sqb.2016.81.031021

St. Pierre, R. and Kadoch, C. (2017). Mammalian SWI/SNF complexes in cancer: emerging therapeutic opportunities. Curr. Opin. Genet. Dev. doi:10.1016/j.gde.2017.02.004

Miller, E.L., Hargreaves, D.C., Kadoch, C., Chang, C.Y., Calarco, J.P., Hodges, C., Buenrostro, J.D., Cui, K., Greenleaf, W.J., Zhao, K., and Crabtree, G.R. (2017). TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin. Nat. Struct. Mol. Biol. 24, 344-352. doi:10.1038/nsmb.3384

Kadoch, C.*, Williams, R.T., Calarco, J.P., Miller, E.L., Weber, C.M., Braun, S.M.G., Pulice, J.L., Chory, E.J. and Crabtree. G.R.* (2016) Dynamics of BAF-Polycomb complex opposition on heterochromatin in normal and oncogenic states. Nat. Genet. 49, 213-222. doi:10.1038/ng.3734 (*Corresponding authors)

Stanton, B.Z., Hodges, C., Calarco, J.P., Braun, S.M.G., Ku, W.L., Kadoch, C., Zhao, K., and Crabtree, G.R. (2017) Smarca4 ATPase mutations disrupt direct eviction of PRC1 from chromatin. Nat. Genet. 49, 282-288, doi:10.1038/ng.3735

2016

Poynter, S. and Kadoch, C. (2016) Polycomb and trithorax opposition in development and disease. WIREs Dev BIo. doi:10.1002/wdev.244

Kadoch, C. (2016) Lifting up the HAT: Synthetic lethal screening reveals a novel vulnerability at the CBP-p300 axis. Cancer Discovery. 6, 430. doi:10.1158/2159-8290.CD-16-0163 (Spotlight Article)

Kadoch, C., Copeland, R.A., and Keilhack, H. (2016) PRC2 and SWI/SNF chromatin remodeling complexes in health and disease. Biochemistry 55, 1600-1614.  doi:10.1021/acs.biochem.5b01191

2013-2015

Kadoch, C. and Crabtree, G.R. (2015) Mammalian SWI/SNF chromatin remodeling complexes and cancer: mechanistic insights gained from human cancer. Sci. Adv. 1, e1500447. doi:10.1126/sciadv.1500447

Kadoch, C., Hargreaves, D.C., Hodges, C., Elias, L., Ho, L., Ranish, J. and Crabtree, G.R. (2013) Proteomic and bioinformatic analysis of the mammalian SWI/SNF complexes identifies extensive roles in human malignancy. Nat. Genet. 45, 592-602. doi:10.1038/ng.2628

Kadoch, C. and Crabtree, G.R. (2013). Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma. Cell 153, 71-85. doi:10.1016/j.cell.2013.02.036

 

Bold denotes authors in the Kadoch Lab