The central focus of our laboratory is to understand BAF complex pathway-of-assembly, to determine the complex subunit and associated protein factor composition of oncogenic BAF complexes, and to define the mechanistic basis of locus-specific and genome-wide retargeting. We aim to create for a new synthesis of concepts and methodologies as novel strategies to target a broad range of human cancers.
Our Research Team
With affiliations to the Dana-Farber Cancer Institute, Harvard Medical School, the Broad Institute of MIT and Harvard, and the Dana-Farber / Harvard Cancer Center, the Kadoch Lab brings together the best of the Harvard research community to tackle unique challenge of unraveling the mechanism of oncogenesis through BAF complex alterations.
From the Forbes 30 Under 30 to the MIT Innovators 35 Under 35, Professor Cigall Kadoch and the Kadoch Lab have received awards and recognition. Learn about recent developments in the Kadoch Lab.