Featured Publications

Bold denotes authors in the Kadoch Lab

A disordered region controls cBAF activity via condensation and partner recruitment

Ajinkya Patil*, Amy R Strom*, Joao A Paulo, Clayton K Collings, Kiersten M Ruff, Min Kyung Shinn, Akshay Sankar, Kasey S Cervantes, Tobias Wauer, Jessica D St Laurent, Grace Xu, Lindsay A Becker, Steven P Gygi, Rohit V Pappu, Clifford P Brangwynne** & Cigall Kadoch**

Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer

Fernando J de Miguel*, Claudia Gentile*, William W Feng, Shannon J Silva, Akshay Sankar, Francisco Exposito, Wesley L Cai, Mary Ann Melnick, Camila Robles-Oteiza, Madeline M Hinkley, Jeanelle A Tsai, Antja-Voy Hartley, Jin Wei, Anna Wurtz, Fangyong Li, Maria I Toki, David L Rimm, Robert Homer, Craig B Wilen, Andrew Z Xiao, Jun Qi, Qin Yan, Don X Nguyen, Pasi A Jänne, Cigall Kadoch**, Katerina A Politi**

Landscape of mSWI/SNF chromatin remodeling complex perturbations in neurodevelopmental disorders

Structural and functional properties of mSWI/SNF chromatin remodeling complexes revealed through single-cell perturbation screens (Molecular Cell, 2023)

Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion (Molecular Cell, 2023)

Pharmacological disruption of mSWI/ SNF complex activity restricts SARS-CoV-2 infection (Nature Genetics, 2023)

Chromatin landscape signals differentially dictate the activities of mSWI/SNF family complexes (Science, 2021)

A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms (Cell, 2020)

The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma (Nature Structural & Molecular Biology, 2020)

Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling (Cell, 2019)

The ATPase module of mammalian SWI/SNF family complexes mediates subcomplex identity and catalytic activity-independent genomic targeting
(Nature Genetics, 2019)

A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation (Nature Cell Biology, 2018)

Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes (Cell, 2018)

Binding of TMPRSS2-ERG to BAF Chromatin Remodeling Complexes Mediates Prostate Oncogenesis (Molecular Cell, 2018)

The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma (Cancer Cell, 2018)

Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens (Cell Systems, 2018)

SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters (Nature Genetics, 2017)

Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain (Cell, 2017)

Dynamics of BAF-Polycomb complex opposition on heterochromatin in normal and oncogenic states (Nature Genetics, 2017)

Proteomic and bioinformatic analysis of the mammalian SWI/SNF complexes identifies extensive roles in human malignancy (Nature Genetics, 2013)

Kadoch, C., Hargreaves, D.C., Hodges, C., Elias, L., Ho, L., Ranish, J. and Crabtree, G.R. (2013) Proteomic and bioinformatic analysis of the mammalian SWI/SNF complexes identifies extensive roles in human malignancy. Nat. Genet. 45, 592-602. doi:10.1038/ng.2628

Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma (Cell, 2013)

Kadoch, C. and Crabtree, G.R. (2013). Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma. Cell 153, 71-85. doi:10.1016/j.cell.2013.02.036

Cell preview

Cancer Cell, June 2018 Issue (33/6)

On the cover: Synovial sarcoma is a rare pediatric cancer in which the hallmark SS18-SSX fusion incorporates into and disrupts BAF complexes to drive tumorigenesis. In this issue, McBride et al. (pp. 1128–1141) demonstrate that the SS18-SSX fusion protein (pirate) confers both gain and loss of genome-wide BAF complex targeting, with BAF complexes (boat) hijacked away from enhancers (green islands) to broad polycomb-repressed domains (gray islands) to activate oncogenic transcription. Cover art by Eric Smith.

Article: McBride, M.J.*, Pulice, J.L.*, Beird, H.C., Ingram, D.R., D'Avino, A.R., Shern, J.F., Charville, G.W., Hornick, J.L., Nakayama, R.T., Garcia-Rivera, E.M., Araujo, D.M., Wang, W., Tsai, J., Yeagley, M., Wagner, A.J., Futreal, P.A., Khan, J., Lazar, A.J., and Kadoch, C.** The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma (2018). Cancer Cell. doi:10.1016/j.ccell.2018.05.002  (* These authors contributed equally, ** Corresponding author)

Cell Systems, May 2018 Issue (6/5)

On the cover: Fitness landscapes. In this issue, Pan et al. (555–568) characterize differential fitness responses to genetic perturbations in cancer cell lines and demonstrate the utility of these fitness profiles in studying gene function. Inspired by the classic album cover of Joy Division's Unknown Pleasures record and enabled by Claus Wilke's R-package “ggridges,” the cover image is an artistic interpretation generated using real data from the fitness responses of 342 cancer cell lines to knockout of individual genes, each represented by a trace. Image credit: Robin Meyers, Joshua Pan, and Eric Smith.

Article: Pan, J.*, Meyers, R.M.*, Michel, B.C., Mashtalir, N.M., Sizemore, A.E., Wells, J.N., Cassel, S.H., Vazquez, F., Weir, B.A., Hahn, W.C., Marsh, J.A., Tserniak, A., and Kadoch, C.** Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens (2018). Cell Systems. doi:10.1016/j.cels.2018.04.011 (* These authors contributed equally, ** Corresponding authors)